Manchester United central midfielder Nemanja Matic is being considered as a doubt to face his one-time side Chelsea after the international break.
A group of sports television channels Sky Sports report that the Serbian could miss the match at Stamford Bridge through injury.
The former Chelsea versatile midfielder has been a key figure for Portuguese manager Jose Mourinho since making the move to the Manchester-based outfit.
The two clubs meet in London in under two weeks time following the second international break of the campaign.
Matic’s injury is the latest blow for the Red Devils, who have endured a difficult start to the season, with concerns over Mourinho’s position at the club.
Jose Mourinho’s side head into the match off the back of a dramatic late victory against Newcastle United on Saturday night.
Mourinho’s men came from behind to victory 3-2, while Chelsea cruised past Southampton with a 3-0 win that took them to the top of the Premier League, level on points with both Manchester City and Liverpool.
This season, in all competitions, Serbia international star has made 8 appearances for Red Devils.